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Wiley InterScience | ||||
  AddictionVolume 102 Issue 3, Pages 389 - 398 Published Online: 8 Feb 2007 Journal compilation © 2010 Society for the Study of Addiction Published on behalf of the Society for the Study of Addiction
Abstract | References | Full Text: HTML, PDF (Size: 256K) | Related Articles | Citation Tracking  RESEARCH REPORT The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption Copyright © 2007 The Authors. Journal compilation © 2007 Society for the Study of Addiction KEYWORDS Adolescent • alcohol drinking • behaviour • environment • genes • juvenile delinquency • risk-taking ABSTRACTAim To investigate possible interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among male adolescents. Design, setting and participants A cross-sectional study of a randomized sample of 66 male individuals from a total population of 16- and 19-year adolescents from a Swedish county. Boys, who volunteered to participate answering an alcohol-related problem/behaviour questionnaire, were investigated with regard to interactions between such problems, family function, maltreatment and MAO-A genotype. Measurements MAO-A genotype, family relations history, history of being maltreated or abused and alcohol-related problem behaviour. Findings Boys with the short (three-repeat) variant of the MAO-A gene, who had been maltreated/abused or came from families with poor relations, showed significantly higher scores of alcohol-related problems. We also found that maltreatment/abuse independently showed the strongest relation to alcohol-related problems among boys in our model. Conclusions The results suggest that both maltreatment and MAO-A genotype may be useful for the understanding of male adolescent alcohol-related problem behaviour. Submitted 12 October 2005; initial review completed 23 January 2006; final version accepted 10 October 2006 | 
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