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Wiley InterScience

Journal of Paediatrics and Child Health

Journal of Paediatrics and Child Health

Volume 43 Issue 7-8, Pages 513 - 521

Published Online: 16 Jul 2007

Journal compilation © 2010 Paediatrics and Child Health Division (Royal Australasian College of Physicians)



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REVIEW ARTICLE
Policy statement on iron deficiency in pre-school-aged children
Cameron C Grant, 1,2 Clare R Wall, 3 David Brewster, 4 Ross Nicholson, 5 John Whitehall, 6 Leanne Super 7 and Lydia Pitcher 8
 Departments of 1Paediatrics and   3 Discipline of Nutrition, University of Auckland,   2 Starship Children's Hospital, Auckland District Health Board, Auckland,   5 Kidz First Children's Hospital, Counties Manukau District Health Board, Manukau, New Zealand,   6 Neonatology, The Townsville Hospital, Newcastle, New South Wales,   8 QML Pathology, Brisbane, Queensland, Australia,   4 Fiji School of Medicine, Suva, Fiji and   7 University College London Hospital, London, UK
Correspondence to  Dr Cameron Grant, Department of Paediatrics, Faculty of Medicine and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand. Fax: +11 649373 7486; email: cc.grant@auckland.ac.nz
Copyright © 2007 The Authors; Journal compilation © 2007 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
KEYWORDS
anaemia iron-deficiency (diagnosis, prevention and control, therapy), Australia • child • iron • New Zealand

ABSTRACT

Aim:  We aimed to develop policy in relation to three areas: (i) the diagnosis of iron deficiency; (ii) maternal–infant issues and the prevention of iron deficiency; and (iii) the treatment of iron deficiency.

Methods:  Within each of these topic areas we completed a literature review and developed recommendations to help direct activities of the Royal Australasian College of Physicians, update paediatricians and guide clinical practice.

Results:  Iron deficiency can be defined using cut-off values for laboratory measures of iron status or, if an intercurrent infection is not present, by demonstrating a response to a therapeutic trial of iron. The appropriate measures of iron status vary depending upon the presence of intercurrent infection. Full-term babies are born with iron stores sufficient to meet their needs to age 4–6 months but premature infants are not. After age 6 months infants are dependent upon dietary iron from complementary foods even with continued breastfeeding. Infants <33 weeks gestation or <1800 g birthweight should receive iron from 4 weeks of age. In most settings recommended treatment of iron deficiency is with oral ferrous sulphate as a single or twice daily dose of between 3 and 6 mg/kg/day.

Conclusions:  Iron deficiency is prevalent and an important determinant of child health. Precise and accurate diagnosis remains challenging. Iron supplementation is required for premature and low-birthweight infants. Oral iron salts remain the recommended treatment of choice in most instances.


Accepted for publication 4 March 2007.

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1440-1754.2007.01128.x About DOI

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