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Wiley InterScience | ||||||||||||
  International Journal of AndrologyVolume 30 Issue 4, Pages 393 - 397 Published Online: 9 Aug 2007 Journal compilation © 2010 European Academy of Andrology The Official Journal of the European Academy of Andrology
Abstract | References | Full Text: HTML, PDF (Size: 467K) | Related Articles | Citation Tracking  REVIEW Epigenetic transgenerational toxicology and germ cell disease Copyright 2007 The Author Journal compilation 2007 Blackwell Publishing Ltd KEYWORDS Epigenetics • Transgenerational • Endocrine Disruptors • DNA Methylation • Sex Determination Summary
The ability of an environmental exposure (i.e. endocrine disruptor) during sex determination to reprogramme the male germline and promote an epigenetic transgenerational disease phenotype suggests that environmental factors and compounds may permanently alter the germline epigenome. This epigenetic transgenerational phenomenon will be discussed with respect to adult-onset germline disease (e.g. testicular cancer). A thorough literature review is not provided, rather a perspective is provided on how this epigenetic transgenerational toxicology should be considered in germ cell disease and testicular cancer. Received 8 December 2006; revised 26 February 2007; accepted 5 March 2007 | 
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