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Wiley InterScience | |||||||||
  Photodermatology, Photoimmunology & PhotomedicineVolume 23 Issue 5, Pages 172 - 178 Published Online: 30 Aug 2007 © 2010 John Wiley & Sons A/S The official publication of the Photomedicine Society, the British Photodermatology Group and the European Society of Photodermatology
Abstract | References | Full Text: HTML, PDF (Size: 141K) | Related Articles | Citation Tracking  UVB therapy increases 25(OH) vitamin D syntheses in postmenopausal women with psoriasis Copyright © 2007 Blackwell Munksgaard KEYWORDS bone mineral density • psoriasis • secondary hyperparathyroidism • UVB therapy • vitamin D ABSTRACTBackground: Vitamin D3 is produced in the epidermis by ultraviolet (UV) radiation (290–315 nm) of 7-dehydrocholesterol. A similar range of 290–320 nm (broadband UVB) has been successfully used for years to treat psoriasis. The aim of this study was to investigate whether UVB therapy was able to influence vitamin D synthesis in psoriasis patients. Methods: Twenty-four postmenopausal, white Caucasian women, aged 69±5.9 (mean±SD), with active plaque psoriasis, were treated with broadband UVB two to three times per week for 8–12 weeks. The serum concentrations of calcidiol (25(OH)D3), calcitriol (1,25(OH) Results: Serum levels of 25(OH)D3 increased from 36.8±17 ng/ml (mean±SD) to 59.6±18.7 ng/ml (P<0.001) after the UVB treatment period. Serum PTH decreased from 62.8±25.7 ng/l to 48.2±17.4 ng/l (P<0.001). Secondary hyperparathyroidism (PTH>65 ng/l) was revealed in seven patients (29%) in whom PTH values were suppressed by the UVB therapy. The serum levels of calcitriol, calcium, osteocalcin, thyroid hormones and creatinine were unaltered. Conclusion: UVB therapy in elderly psoriatic women improved psoriasis, increased serum 25(OH)D3 synthesis and reduced serum PTH concentrations. Accepted for publication 4 May 2007 | 
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