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Wiley InterScience | |||||||||||||||||||
  International Journal of Experimental PathologyVolume 88 Issue 2, Pages 103 - 110 Published Online: 20 Dec 2006 Journal compilation © 2010 Blackwell Publishing Ltd
Abstract | References | Full Text: HTML, PDF (Size: 594K) | Related Articles | Citation Tracking  REVIEW ARTICLE Inflammation-associated remodelling and fibrosis in the lung – a process and an end point Copyright 2007 Blackwell Publishing Ltd KEYWORDS fibrosis • inflammation • injury • lung • remodelling Summary
Fibrosis by common usage in the pathological and clinical literature is the end result of a healing process and synonymous with scarring. We would argue that its use to describe a dynamic series of events which may be reversible is unhelpful and that the term 'lung remodelling' is a better description for this process as it reflects changes in tissue organization that may or may not progress to 'fibrosis' as a final fixed point. Resolution, through reversal of active lung remodelling, by therapeutic intervention is possible providing the alveolar architecture remains intact. If the lung architecture is lost then healing by permanent fibrosis with loss of organ function is inevitable. Received for publication: 16 October 2006 Accepted for publication: 16 October 2006 | 
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