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Wiley InterScience | ||||
  Paediatric and Perinatal EpidemiologyVolume 21 Issue s3, Pages 23 - 28 Published Online: 11 Oct 2007 © 2010 Blackwell Publishing Ltd. Affiliated to the Society for Pediatric and Perinatal Epidemiologic Research
Abstract | References | Full Text: HTML, PDF (Size: 106K) | Related Articles | Citation Tracking  Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation Copyright © 2007 The Authors. Journal Compilation © 2007 Blackwell Publishing Ltd KEYWORDS randomised controlled trial • probiotics • asthma • hygiene hypothesis Cabana MD, McKean M, Wong AR, Chao C, Caughey AB. Examining the hygiene hypothesis: the Trial of Infant Probiotic Supplementation. Paediatric and Perinatal Epidemiology 2007; 21(Suppl. 3): 23–28.
ABSTRACTThe hygiene hypothesis suggests that the absence of infectious exposure at a critical point in immune system development leads to a greater risk for the later development of atopic disease. As a result, it may be possible to devise strategies that can block the onset of atopic diseases such as asthma. This paper outlines the rationale, background and design for the Trial of Infant Probiotic Supplementation study, which is designed to test the effectiveness of a daily infant probiotic supplement in the first 6 months of life in preventing the development of early markers of asthma. | 
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