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Wiley InterScience | ||||||||||
  EchocardiographyVolume 24 Issue 4, Pages 412 - 419 Published Online: 21 Mar 2007 Journal compilation © 2009 Wiley Periodicals, Inc.
Abstract | References | Full Text: HTML, PDF (Size: 178K) | Related Articles | Citation Tracking  Initial Experience with High Frequency Ultrasound for the Newborn C57BL Mouse Copyright 2007, the Authors Journal compilation © 2007, Blackwell Publishing, Inc. KEYWORDS
congenital heart disease
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ultrasound imaging
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newborn mouse
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M = mode
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Doppler
(ECHOCARDIOGRAPHY, Volume 24, April 2007) ABSTRACTThe mouse has become a powerful genetic tool for studying genes involved in cardiac development and congenital heart disease. Many of the most severe congenital heart defects are ductal-dependent, resulting in neonatal lethality. Recent advances in ultrasound technology provide an opportunity for the use of high-frequency transducers to characterize the cardiac anatomy and physiology of the newborn mouse. In this study, we define limited normative values for cardiac structure and function in the C57BL newborn mouse. Specifically, we define normal values for 19 indices derived from standard echocardiographic views. This study demonstrates that transthoracic echocardiography using a 40-MHz high-frequency transducer is a safe and reliable noninvasive modality for the delineation of cardiac anatomy and physiology in the newborn mouse. | 
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