Diabetes mellitus and kidney cancer risk: The results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)

doi:10.1111/j.1442-2042.2007.01744.x

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Wiley InterScience

International Journal of Urology

Volume 14 Issue 5, Pages 393 - 397

Published Online: 15 May 2007

The Official Journal of the Japanese Urological Association

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Original Article: Clinical Investigation

Diabetes mellitus and kidney cancer risk: The results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)

Masakazu Washio, ^1,2 Mitsuru Mori, ¹ Mmh Khan, ¹ Fumio Sakauchi, ¹ Yoshiyuki Watanabe, ³ Kotaro Ozasa, ³ Kyohei Hayashi, ³ Tsuneharu Miki, ⁴ Masahiro Nakao, ⁴ Kazuya Mikami, ⁴ Yoshinori Ito, ^5,8 Tatsuhiko Kubo, ⁶ Kenji Wakai ^7,8 and Akiko Tamakoshi ⁸ For The JACC Study Group

¹ Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, ² Department of Community Health and Clinical Epidemiology, St. Mary's College, Fukuoka, ³ Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, ⁴ Department of Urology, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, ⁵ Department of Public Health, Fujita Health University School of Health Sciences, Fujita, ⁶ Department of Clinical Epidemiology, University of Occupational Health and Environmental Health, Kitakyushu, ⁷ Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, ⁸ Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan

Correspondence to Masakazu Washio md, Department of Community Health and Clinical Epidemiology, St. Mary's College, 422 Tsubuku-hon-machi, Kurume City, Fukuoka 830-8558, Japan. Email: washio@st-mary.ac.jp

KEYWORDS

diabetes mellitus • Japan • renal cell carcinoma • risk factor

ABSTRACT

Background: Diabetes mellitus (DM) is reported as being a risk factor associated with kidney cancer in Western countries. The incidence of both kidney cancer and DM is lower in Japan than the other developed countries, albeit on the rise.

Methods: We evaluated the risk factors for kidney cancer mortality using the database of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) study. The analytic cohort included 46 462 males and 64 326 females aged 40–79 years old. The Cox proportional hazards model was used to determine age- and sex-adjusted relative risk and its 95% confidence intervals.

Results: DM showed an increased, age- and sex-adjusted hazard ratio for kidney cancer mortality, but it failed to achieve statistical significance after controlling for other factors.

Conclusion: The present study showed that DM increased the risk of kidney cancer death among the Japanese population. However, further studies may be needed to confirm the findings in the present study because DM failed to remain as a significant risk factor after controlling for other factors because of the small number of kidney cancer deaths in the present study.

Received 16 June 2006; accepted 14 December 2006.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1442-2042.2007.01744.x About DOI