Focal Hyperhidrosis of the Anal Fold: Successful Treatment with Botulinum Toxin A

doi:10.1111/j.1524-4725.2007.33193.x

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Wiley InterScience

Dermatologic Surgery

Volume 33 Issue 8, Pages 924 - 927

Published Online: 2 May 2007

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Focal Hyperhidrosis of the Anal Fold: Successful Treatment with Botulinum Toxin A

FALK G. BECHARA, MD ^* , MICHAEL SAND, MD ^* , REINHARD K. ACHENBACH, MD ^† , DANIEL SAND, BS ^‡ , PETER ALTMEYER, MD ^* , AND KLAUS HOFFMANN, MD ^*

^* Department of Dermatology and Allergology, Ruhr-University Bochum, Bochum, Germany; ^† Private Practice, Herford, Germany; ^‡ Department of Physiological Science, University of California at Los Angeles (UCLA), Los Angeles, California

Address correspondence and reprint requests to: Falk Georges Bechara, MD, Department of Dermatology and Allergology, Ruhr-University Bochum, St. Josef Hospital, Gudrunstrasse 56, 44791 Bochum, Germany, or e-mail: f.bechara@derma.de

The authors have indicated no significant interest with commercial supporters.

ABSTRACT

BACKGROUND Treatment of focal hyperhidrosis with botulinum toxin A (BTX-A) is known to be effective in the axillary, palmar, and plantar region. No studies evaluating the treatment of hyperhidrosis in the anal fold with BTX-A are available, however.

OBJECTIVE The objective was to evaluate whether or not injections with BTX-A are an effective therapy option for the treatment of focal hyperhidrosis of the anal fold.

MATERIAL AND METHODS Eleven male patients (median age, 28.3 years) with focal hyperhidrosis of the anal fold as assessed by modified iodine-starch test were enrolled. Each patient received intradermal injections with 38 U on average (30–54 U) of BTX-A (BOTOX, Allergan Inc.). Changes in sweat rates were documented by comparing the size of hyperhidrotic area in square centimeters before and 4 weeks after injection.

RESULTS The mean reduction of hyperhidrotic area was 29.9 cm² (range, 27–43 cm²), corresponding to a reduction of 78.5%. Apart from painful injections, no side effects were observed.

CONCLUSION BTX-A is an effective therapy for patients with focal hyperhidrosis of the anal fold.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1524-4725.2007.33193.x About DOI