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Wiley InterScience | |||||
  Tissue AntigensVolume 70 Issue 2, Pages 151 - 156 Published Online: 8 May 2007 © 2010 John Wiley & Sons A/S The official journal of the European Federation for Immunogenetics
Abstract | References | Full Text: HTML, PDF (Size: 117K) | Related Articles | Citation Tracking  BRIEF COMMUNICATION The genetic variation of the human HMGB1 gene Copyright 2007 The Authors Journal compilation KEYWORDS cytokines • HMGB1 • inflammation • innate immunity • polymorphisms ABSTRACTHigh-mobility group box 1 protein (HMGB1) is a nuclear DNA-binding protein, which also functions as a pleiotropic cytokine, implicated in the pathology of several different immune-mediated diseases. The purpose of this study was to examine the HMGB1 gene for putative polymorphisms in 103 healthy Caucasian Danish blood donors. A total of six polymorphisms and four mutations were identified in the HMGB1 gene. Subsequent MatInspector estimation revealed that several polymorphisms might have a potential regulatory impact on HMGB1 transcription. This study has characterized genetic variations in the HMGB1 gene locus, which may have a regulating role in the expression of HMGB1, providing the basis for molecular investigations of the HMGB1 gene in different disease settings. Received 17 January 2007; revised 23 February 2007, 28 March 2007; accepted 12 April 2007 | 
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