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Wiley InterScience | ||||||
  Acta Biochimica et Biophysica SinicaVolume 39 Issue 6, Pages 399 - 405 Published Online: 26 Jun 2007 © 2008 Institute of Biochemistry and Cell Biology, SIBS, CAS
Abstract | References | Full Text: PDF (Size: 385K) | Related Articles | Citation Tracking  Microarray Analysis of the Developing Rat Mandible This work was supported by a grant from the Ministry of Education, Culture, Sports, Science, and Technology, Japan Copyright 2007 Institute of Biochemistry and Cell Biology, SIBS, CAS KEYWORDS gene expression • microarray • rat mandible Abstract
To analyze the molecular events that occur in the developing mandible, we examined the expression of 8803 genes from samples taken at different time points during rat postnatal mandible development. Total RNA was extracted from the mandibles of 1-day-old, 1-week-old, and 2-week-old rats, Complementary RNA (cRNA) was synthesized from cDNA and biotinylated. Fragmented cRNA was hybridized to RGU34A GeneChip arrays. Among the 8803 genes tested, 4344 were detectable. We identified 148 genes with significantly increased expressions, and 19 genes with significantly decreased expression. A Comprehensive analysis appears to be an effective method of studying the complex process of development. Received: November 17, 2006 Accepted: March 14, 2007 | 
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