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Off-label uses of rituximab in dermatology
David R. Carr & Michael P. Heffernan
Division of Dermatology, Wright State University, Dayton, Ohio
Address correspondence and reprint requests to: Michael P. Heffernan, MD, Chief, Division of Dermatology; Associate Professor of Dermatology, Wright State University School of Medicine, One Elizabeth Place, Suite 200, Dayton, OH 45408-1445, or email: michael.heffernan@wright.edu.

This paper is completely self-generated and has not received any outside funding. This paper only reflects the views of its authors.

Dr Heffernan has been a paid investigator, lecturer and/or consultant for Abbott, Amgen, Biogen-IDEC, Centocor and Genentech.

Contents of this manuscript were presented at the 64th Annual Meeting of the American Academy of Dermatology.

Copyright © Blackwell Publishing, Inc., 2007
KEYWORDS
biologics • rituximab

ABSTRACT

ABSTRACT:  Since its approval in 1997 by the FDA, rituximab has been approved for use in certain B-cell lymphomas and treatment-resistant rheumatoid arthritis. Over the past 10 years, many case reports have indicated rituximab's efficacy in a number of inflammatory conditions in dermatology. This article includes a review of the mechanism of action, dosing, and side effect profile, as well as a review of the current literature on off-label uses of the CD20+ B-cell antagonist rituximab.


DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1529-8019.2007.00141.x About DOI

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