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Wiley InterScience | ||||||||||
  Chemical Biology & Drug DesignVolume 70 Issue 1, Pages 13 - 18 Published Online: 25 Jun 2007 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 226K) | Supporting Information | Related Articles | Citation Tracking  Research Article Nanoparticles Featuring Amino Acid-functionalized Side Chains as DNA Receptors Copyright 2007 The Authors Journal compilation 2007 Blackwell Munksgaard KEYWORDS amino acid • DNA • nanoparticle ABSTRACTA family of nanoparticles has been fabricated featuring cationic amino acid-based side chains. This controlled surface modification provides a tool to investigate the effect of various non-covalent interactions at the nanoparticle–DNA interface. The binding affinities of these nanoparticles towards DNA were determined using fluorescence, exhibiting more than threefold modulation in binding a 37-mer DNA strand. The secondary structure of the DNA strand was distorted upon nanoparticle binding, with the extent of distortion dependent on the structure of amino acid side chain. Received 1 June 2007, revised 1 June 2007 and accepted for publication 2 June 2007 | 
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