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Wiley InterScience | |||||||||||
Abstract | References | Full Text: HTML, PDF (Size: 470K) | Related Articles | Citation Tracking  CASE REPORT Fertilisation failure after intracytoplasmic sperm injection is not associated with sperm aneuploidy of a globozoospermic patient Copyright 2007 The Authors Journal Compilation 2007 Blackwell Publishing Ltd KEYWORDS Aneuploidy • FISH • globozoospermia • round-headed sperm Summary
The objective of this study was to determine the aneuploidy rate in spermatozoa from a globozoospermic patient who underwent three unsuccessful intracytoplasmic sperm injection (ICSI) treatment cycles together with his wife. The aneuploidy rates of chromosomes 13, 18, 21, X and Y as well as the diploidy rate in the spermatozoa of this man were evaluated by fluorescence in situ hybridisation to clarify if chromosomal aneuploidy could be a cause for the low fertilisation rate observed in this case. In the spermatozoa of our patient no increase in aneuploidy rates was found for the tested chromosomes (0.0% disomies of chromosomes 13, 18 and 21 with a diploidy rate of 0.6%; X/Y missegregation: 0.6%) indicating that the ICSI outcome of the couple was not impaired by sperm aneuploidy of the globozoospermic man. Accepted: October 25, 2006 | 
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