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Wiley InterScience | ||
 
Abstract | References | Full Text: HTML, PDF (Size: 50K) | Related Articles | Citation Tracking  Traffic Jams: Dynamic Models for Neurofilament Accumulation in Motor Neuron Disease Copyright 2007 The Authors Journal compilation KEYWORDS ALS • axonal transport • density waves • dynein • neurofilaments • motor neuron disease ABSTRACTThe dynamics of axonal transport are often colloquially described using highway traffic as a model system. Examination of the physics of traffic patterns, with emphasis on traffic jams and accidents, provides unique and perhaps counterintuitive insight into the aberrant accumulation of neurofilaments that accompanies amyotrophic lateral sclerosis/motor neuron disease. Received 29 September 2006, revised and accepted for publication 4 January 2007, published online 19 February 2007 |
