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Wiley InterScience

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Case Report
Renal Pathology and Urinary Protein Excretion in a 14-Month-Old Bernese Mountain Dog with Chronic Renal Failure
J. Raila 1,4 , H. Aupperle 2 , G. Raila 3 , H. -A. Schoon 2 and F. J. Schweigert 1
Address of authors:  1Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114–116, 14558 Nuthetal (Potsdam-Rehbrücke);  2Institute of Veterinary Pathology, University of Leipzig, An den Tierkliniken 33, 04103 Leipzig;  3Veterinary Clinic for Small Animals, Lusaner Straße 20, 07549 Gera, Germany;  4Corresponding author: Tel.: +49 33200 88 532; fax: +49 33200 88 573; E-mail: jraila@rz.uni-potsdam.de
Correspondence to Institute of Nutritional Science, University of Potsdam, Nuthetal (Potsdam-Rehbrücke), Germany
Copyright 2007 The Authors Journal compilation 2007 Blackwell Verlag, Berlin

Summary

AbstractIntroductionCase PresentationDiscussionAcknowledgementsReferences

The renal pathology and urinary protein pattern of a 14-month-old female Bernese mountain dog with chronic renal failure was investigated. Sodium dodecyl sulphate-polyacrylamid gel electrophoresis and subsequent Western blot analysis of urine showed the presence of heavy and light chains of immunoglobulin, transferrin, albumin, vitamin D-binding protein, transthyretin and retinol-binding protein (RBP), but no excretion of Tamm–Horsfall protein (THP). Histopathological examinations of the kidneys revealed severe membranous glomerulonephritis accompanied by tubular dilatation, tubular atrophy and interstitial fibrosis. The renal expression of megalin, the main endocytic receptor for the re-uptake of proteins in proximal tubules, RBP and THP was reduced or completely absent, indicating severe tubular dysfunction. The identified urinary proteins may be of interest as additional markers for the diagnosis of juvenile nephropathy in Bernese mountain dogs.

With 1 table and 3 figures&Received for publication May 30, 2006

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1439-0442.2007.00919.x About DOI

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