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Wiley InterScience | |||||||||||||||||
  Annals of Human GeneticsVolume 70 Issue 6, Pages 867 - 881 Published Online: 16 May 2006 Journal compilation © 2010 Blackwell Publishing Ltd/University College London
Abstract | References | Full Text: HTML, PDF (Size: 255K) | Related Articles | Citation Tracking  QTL Mapping Under Ascertainment Copyright 2006 The Authors Journal compilation © 2006 University College London KEYWORDS Gene mapping • Quantitative trait • Ascertainment • Efficient score ABSTRACTMapping quantitative trait loci (QTL) using ascertained sibships is discussed. It is shown that under the standard normality assumption of variance components analysis the efficient scores are unchanged by ascertainment, and two different schemes of ascertainment correction suggested in the literature are asymptotically equivalent. The use of conditional maximum likelihood estimators derived under the normality assumption to estimate nuisance parameters is shown to result in only a small loss of power compared to the case of known parameters, even when the distribution of phenotypes is non-normal and/or the ascertainment criterion is ill defined.
Received: 2 October 2005 | 
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