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Wiley InterScience | |||||||||||
  Diabetic MedicineVolume 23 Issue 4, Pages 432 - 435 Published Online: 24 Mar 2006 Journal compilation © 2010 Diabetes UK
Abstract | References | Full Text: HTML, PDF (Size: 81K) | Related Articles | Citation Tracking  Severe acidosis in patients taking metformin—rapid reversal and survival despite high APACHE score Copyright © 2006 The Author Journal compilation
© 2006 Diabetes UK KEYWORDS lactic acidosis • metformin • renal failure • Type 2 diabetes Abstract
Background Metformin has been shown to reduce complications and mortality from Type 2 diabetes mellitus, and is increasingly used to treat this condition. This agent is, however, associated with a rare but serious risk of lactic acidosis. Case report We present cases of 10 patients with Type 2 diabetes mellitus who developed acute renal failure and severe lactic acidosis. Despite the severity of their illness, all patients but one survived. Conclusions The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis. However our case report demonstrates that early and aggressive treatment with haemofiltration can improve outcomes even in the presence of severe acidosis. Diabet. Med. 23, 432–435 (2006) Accepted 20 September 2005 | 
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