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Wiley InterScience | ||||||||||||
  Diabetic MedicineVolume 23 Issue 8, Pages 857 - 866 Published Online: 26 Jun 2006 Journal compilation © 2010 Diabetes UK
Abstract | References | Full Text: HTML, PDF (Size: 139K) | Related Articles | Citation Tracking  Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999 Copyright © 2006 The Authors. Journal compilation © 2006 Diabetes UK. Diabetic Medicine KEYWORDS epidemiology • geographical distribution • incidence • trend • Type 1 diabetes Diabet. Med. 23, 857–866 (2006) Abstract
Aims To examine incidence and trends of Type 1 diabetes worldwide for the period 1990–1999. Methods The incidence of Type 1 diabetes (per 100 000/year) was analysed in children aged ≤ 14 years from 114 populations in 112 centres in 57 countries. Trends in the incidence of Type 1 diabetes were analysed by fitting Poisson regression models to the dataset. Results A total of 43 013 cases were diagnosed in the study populations of 84 million children. The age-adjusted incidence of Type 1 diabetes among 112 centres (114 populations) varied from 0.1 per 100 000/year in China and Venezuela to 40.9 per 100 000/year in Finland. The average annual increase in incidence calculated from 103 centres was 2.8% (95% CI 2.4–3.2%). During the years 1990–1994, this increase was 2.4% (95% CI 1.3–3.4%) and during the second study period of 1995–1999 it was slightly higher at 3.4% (95% CI 2.7–4.3%). The trends estimated for continents showed statistically significant increases all over the world (4.0% in Asia, 3.2% in Europe and 5.3% in North America), except in Central America and the West Indies where the trend was a decrease of 3.6%. Only among the European populations did the trend in incidence diminish with age. Conclusions The rising incidence of Type 1 diabetes globally suggests the need for continuous monitoring of incidence by using standardized methods in order to plan or assess prevention strategies. Accepted 1 February 2006 | 
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