T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities

doi:10.1111/j.1600-0463.2006.apm_458.x

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Wiley InterScience

APMIS

Volume 114 Issue 6, Pages 474 - 478

Published Online: 4 Jul 2006

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T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities

Case report

LAURENCE DE LEVAL, ¹ NANCY LEE HARRIS, ² SERGE LAMPERTZ ³ and CHRISTIAN HERENS ¹

Departments of ¹Pathology and ⁴Genetics, CHU Sart-Tilman, Liège, Belgium ² Department of Pathology, Massachusetts General Hospital, Boston, MA, USA ³ Department of Hematology, Centre Hospitalier du Bois de l'Abbaye, Seraing, Belgium

Correspondence to Laurence de Leval, Department of Pathology, CHU Sart-Tilman, Tour de Pathologie, B23, B-4000 Liège, Belgium. e-mail: L.deLeval@ulg.ac.be

Received 28 February 2006.

Accepted 3 March 2006.

KEYWORDS

T-cell/histiocyte-rich large B-cell lymphoma • cytogenetics • karyotype • chromosome

de Leval L, Harris NL, Lampertz S, Herens C. T-cell/histiocyte-rich large B-cell lymphoma associated with a near-tetraploid karyotype and complex genetic abnormalities. APMIS 2006;114:474–8.

ABSTRACT

Cytogenetic data for T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) are scarcely available. We report here a case of THRLBCL with a near-tetraploid karyotype and complex chromosomal aberrations, without rearrangement of BCL2 or BCL6, and characterized pathologically by a variegated morphologic appearance with areas resembling nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL).

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1600-0463.2006.apm_458.x About DOI