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Wiley InterScience | |||||||
  Dermatologic SurgeryVolume 32 Issue 5, Pages 645 - 650 Published Online: 12 May 2006 © 2010 American Society of Dermatologic Surgery
Abstract | References | Full Text: HTML, PDF (Size: 478K) | Related Articles | Citation Tracking  Treatment of Depression with Botulinum Toxin A: A Case Series Copyright © 2006 by the American Society for Dermatologic Surgery, Inc. Dr. Finzi has applied for a patent using botulinum toxin A to treat depression. ABSTRACTBACKGROUND Major depression is a common and serious disease that may be resistant to routine pharmacologic and psychotherapeutic treatment approaches. OBJECTIVE To evaluate the efficacy of botulinum toxin A treatment of glabellar frown lines in treating patients with major depression, using a small open pilot trial. METHODS Patients who met DSM-IV criteria for ongoing major depression in spite of pharmacologic or psychotherapeutic treatment were evaluated with the Beck Depression Inventory II (BDI-II) before receiving botulinum toxin A to their glabellar frown lines. Two months later, all patients were re-evaluated clinically and with the BDI-II. RESULTS Ten depressed patients were treated with botulinum toxin A, and 9 of 10 patients were no longer depressed 2 months after treatment. The tenth patient had an improvement in mood. CONCLUSION To our knowledge, these are the first reported cases of depression treated with botulinum toxin A. | 
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