International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

doi:10.1111/j.1538-7836.2006.01753.x

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Wiley InterScience

Journal of Thrombosis and Haemostasis

Volume 4 Issue 2, Pages 295 - 306

Published Online: 13 Jan 2006

The official journal of the International Society on Thrombosis and Haemostasis

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SPECIAL ARTICLE

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

S. MIYAKIS*, M. D. LOCKSHIN†, T. ATSUMI‡, D. W. BRANCH§, R. L. BREY¶, R. CERVERA**, R. H. W. M. DERKSEN††, P. G. DE GROOT††, T. KOIKE‡, P. L. MERONI‡‡, G. REBER§§, Y. SHOENFELD¶¶, A. TINCANI***, P. G. VLACHOYIANNOPOULOS††† and S. A. KRILIS*

*St George Hospital, University of New South Wales, Sydney, Australia ; †Hospital for Special Surgery, Cornell Medical Center, New York, NY, USA ; ‡Hokkaido University, Sapporo, Japan ; §University of Utah Health Sciences Center, Salt Lake City, UT ; ¶University of Texas Health Science Center, San Antonio, TX, USA ; **Hospital Clinic, Barcelona, Spain ; ††University Medical Center, Utrecht, The Netherlands ; ‡‡Istituto Auxologico Italiano, University of Milan, Milan, Italy ; §§University Hospital, Geneva, Switzerland ; ¶¶Sheba Medical Center, Tel-Hashomer and Tel Aviv University, Israel ; ***Spedali Civili, University of Brescia, Italy ; and †††Department of Pathophysiology, University of Athens, Greece

Correspondence to Steven A. Krilis, Department of Immunology, Allergy and Infectious Disease, St George Hospital, 2 South St, Kogarah, NSW 2217, Australia.
Tel.: +612 93502955; fax: +61293503981; e-mail: s.krilis@unsw.edu.au

KEYWORDS

anticardiolipin • antiphospolipid syndrome • β ₂ glycoprotein-I • classification criteria • lupus anticoagulant • thrombosis

ABSTRACT

Summary. New clinical, laboratory and experimental insights, since the 1999 publication of the Sapporo preliminary classification criteria for antiphospholipid syndrome (APS), had been addressed at a workshop in Sydney, Australia, before the Eleventh International Congress on antiphospholipid antibodies. In this document, we appraise the existing evidence on clinical and laboratory features of APS addressed during the forum. Based on this, we propose amendments to the Sapporo criteria. We also provide definitions on features of APS that were not included in the updated criteria.

Received 30 August 2005, accepted 2 November 2005

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1538-7836.2006.01753.x About DOI