The Effects of 6 Months of Increased Water Intake on Blood Sodium, Glomerular Filtration Rate, Blood Pressure, and Quality of Life in Elderly (Aged 55–75) Men

doi:10.1111/j.1532-5415.2005.00606.x

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Wiley InterScience

Journal of the American Geriatrics Society

Volume 54 Issue 3, Pages 438 - 443

Published Online: 24 Jan 2006

Journal compilation 2010 The American Geriatrics Society/Wiley Periodicals, Inc.

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The Effects of 6 Months of Increased Water Intake on Blood Sodium, Glomerular Filtration Rate, Blood Pressure, and Quality of Life in Elderly (Aged 55–75) Men

Mark G. Spigt, PhD ^* , J. A. Knottnerus, MD, PhD ^* , Klaas R. Westerterp, PhD ^† , Marcel G. M. Olde Rikkert, MD, PhD ^‡ , and C. P. van Schayck, PhD ^*

From the ^*Department of General Practice, Research Institute Caphri, and ^†Department of Human Biology, Research Institute Nutrim, Maastricht University, Maastricht, the Netherlands; and ^‡Department of Geriatrics, University Medical Center, Nijmegen, the Netherlands.

Address correspondence to Mark Spigt, Maastricht University, Department of General Practice, PO Box 616,6200 MD Maastricht, the Netherlands. E-mail: m.spigt@hag.unimaas.nl

This study was financed by the Netherlands Organization for Health Research and Development.

KEYWORDS

dehydration • hyponatremia • blood pressure • water

ABSTRACT

OBJECTIVES: To study whether there are any negative or positive effects of 6 months of increased fluid intake in reasonably healthy elderly men.

DESIGN: Randomized trial.

SETTING: Community-based.

PARTICIPANTS: One hundred forty-one healthy participants aged 55 to 75.

INTERVENTION: One group was given the advice to increase their daily fluid intake by 1.5 L of water; the other group was given placebo medication (8 mL inactive syrup per day).

MEASUREMENTS: At 6 months blood sodium, glomerular filtration rate (GFR), blood pressure, and quality of life (QOL) were measured. The changes in water turnover were measured using deuterium.

RESULTS: Most subjects did not manage to increase their fluid intake by 1.5 L. The average increase in the intervention group was approximately 1 L. Twenty-four-hour water turnover in the water group was 359 mL (95% confidence interval=171–548) higher than that of the control group at 6-month follow-up. Blood pressure, sodium level, GFR, and QOL did not change significantly in either group during the intervention period. In addition, the cases reporting a worsening on the effect measures were equally distributed over the two study groups.

CONCLUSION: The advice to increase fluid intake by 1.5 L had no negative effects in reasonably healthy men aged 55 to 75.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1532-5415.2005.00606.x About DOI