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Wiley InterScience | |||||
  Tissue AntigensVolume 67 Issue 3, Pages 229 - 232 Published Online: 8 Mar 2006 © 2010 John Wiley & Sons A/S The official journal of the European Federation for Immunogenetics
Abstract | References | Full Text: HTML, PDF (Size: 90K) | Related Articles | Citation Tracking  BRIEF COMMUNICATION Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis Copyright Blackwell Munksgaard, 2006 KEYWORDS cytokine gene • lungfibrosis •
polymorphism
ABSTRACTAbstractWe investigated 30 patients with idiopathic pulmonary fibrosis (IPF) and 103 healthy volunteers for the cytokines polymorphisms of the IL-1α, IL-1β, IL-1R, IL-1RA, IL-2, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor-α, interferon-γ, transforming growth factor-β, IL-1β, IL-2, IL-4, and IL-4RA genes. The strongest correlation of a genotype with the disease was found for gene polymorphisms at the promotor region of IL-4, where the CT genotypes at the positions (−590) and (−33) were more frequent in the IPF group (P < 0.0001, P Received 3 October 2005; revised 8 November 2005; accepted 22 December 2005 | 
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