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Wiley InterScience | |||||||
![]() Australian and New Zealand Journal of Obstetrics and GynaecologyVolume 46 Issue 2, Pages 159 - 163 Published Online: 3 Apr 2006 Journal compilation © 2009 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
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A possible role for progesterone metabolites in human parturition DOI: 10.1111/j.1479-828X.2006.00548.x Copyright © 2006 The Author
Journal compilation © 2006 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists KEYWORDS human • parturition • progesterone metabolites • progesterone Abstract
There has been a recent resurgence of interest in the role of progesterone in the maintenance of human pregnancy and the onset of labour, following recent reports of its use to prevent preterm labour in high-risk patients. One possible mechanism by which progesterone might contribute to uterine quiescence is through the actions of its metabolites. This article provides a brief overview of progesterone in human pregnancy and an outline of progesterone metabolism in the various reproductive tract tissues as well as the evidence for actions of progesterone metabolites in pregnancy. Received 09 December 2005; accepted 03 January 2006. |