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Wiley InterScience

Australian and New Zealand Journal of Obstetrics and Gynaecology

Australian and New Zealand Journal of Obstetrics and Gynaecology

Volume 46 Issue 2, Pages 159 - 163

Published Online: 3 Apr 2006

Journal compilation © 2009 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists



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Research Showcase
A possible role for progesterone metabolites in human parturition
Penelope M. SHEEHAN
Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women's Hospital, Carlton, Victoria, Australia
Correspondence: Dr Penelope Sheehan, Pregnancy Research Centre, Royal Women's Hospital, 132 Grattan Street, Carlton, Vic. 3053, Australia. Email: penny.sheehan@rwh.org.au

DOI: 10.1111/j.1479-828X.2006.00548.x

Copyright © 2006 The Author
Journal compilation © 2006 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
KEYWORDS
human • parturition • progesterone metabolites • progesterone

Abstract

AbstractIntroductionConclusionAcknowledgementsReferences

There has been a recent resurgence of interest in the role of progesterone in the maintenance of human pregnancy and the onset of labour, following recent reports of its use to prevent preterm labour in high-risk patients. One possible mechanism by which progesterone might contribute to uterine quiescence is through the actions of its metabolites. This article provides a brief overview of progesterone in human pregnancy and an outline of progesterone metabolism in the various reproductive tract tissues as well as the evidence for actions of progesterone metabolites in pregnancy.


Received 09 December 2005; accepted 03 January 2006.

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1479-828X.2006.00548.x About DOI

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