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Wiley InterScience | ||||||||||||
  Animal GeneticsVolume 37 Issue 2, Pages 163 - 165 Published Online: 23 Nov 2005 Journal compilation © 2010 Stichting International Foundation for Animal Genetics Published on behalf of the International Society for Animal Genetics
Abstract | References | Full Text: HTML, PDF (Size: 219K) | Supporting Information | Related Articles | Citation Tracking  SHORT COMMUNICATION
White spotting in the domestic cat (Felis catus) maps near KIT on feline chromosome B1 Copyright 2005 The Authors, Journal Compilation 2005 European Society for Evolutionary Biology ABSTRACTFive feline-derived microsatellite markers were genotyped in a large pedigree of cats that segregates for ventral white spotting. Both KIT and EDNRB cause similar white spotting phenotypes in other species. Thus, three of the five microsatellite markers chosen were on feline chromosome B1 in close proximity to KIT; the other two markers were on feline chromosome A1 near EDNRB. Pairwise linkage analysis supported linkage of the white spotting with the three chromosome B1 markers but not with the two chromosome A1 markers. This study indicates that KIT, or another gene within the linked region, is a candidate for white spotting in cats. Platelet-derived growth factor alpha (PDGFRA) is also a strong candidate, assuming that the KIT–PDGFRA linkage group, which is conserved in many mammalian species, is also conserved in the cat. Accepted for publication 18 September 2005 | 
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