The Tabby cat locus maps to feline chromosome B1

doi:10.1111/j.1365-2052.2006.01458.x

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Wiley InterScience

Animal Genetics

Volume 37 Issue 4, Pages 383 - 386

Published Online: 16 May 2006

Published on behalf of the International Society for Animal Genetics

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SHORT COMMUNICATION

The Tabby cat locus maps to feline chromosome B1

L. A. Lyons*, S. J. Bailey ^† , K. C. Baysac*, G. Byrns ^‡ , C. A. Erdman*, N. Fretwell ^† , L. Froenicke*, K. W. Gazlay*, L. A. Geary*, J. C. Grahn*, R. A. Grahn*, G. M. Karere*, M. J. Lipinski*, H. Rah*, M. T. Ruhe* and L. H. Bach*

*Population Health and Reproduction, School of Veterinary Medicine, University of California – Davis, Davis, CA 95616, USA . ^† WALTHAM Centre for Pet Nutrition, Melton Mowbray, Leicestershire, UK . ^‡ Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California – Davis, Davis, CA 95616, USA

Correspondence to L. A. Lyons, Population Health and Reproduction, School of Veterinary Medicine, University of California – Davis, Davis, CA 95616, USA.
E-mail: lalyons@ucdavis.edu

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

KEYWORDS

Abyssinian • blotched • cat • classic • Felis catus • mackerel • Tabby

ABSTRACT

The Tabby markings of the domestic cat are unique coat patterns for which no causative candidate gene has been inferred from other mammals. In this study, a genome scan was performed on a large pedigree of cats that segregated for Tabby coat markings, specifically for the Abyssinian (T ^a-) and blotched (t^bt^b) phenotypes. There was linkage between the Tabby locus and eight markers on cat chromosome B1. The most significant linkage was between marker FCA700 and Tabby (Z = 7.56, θ = 0.03). Two additional markers in the region supported linkage, although not with significant LOD scores. Pairwise analysis of the markers supported the published genetic map of the cat, although additional meioses are required to refine the region. The linked markers cover a 17-cM region and flank an evolutionary breakpoint, suggesting that the Tabby gene has a homologue on either human chromosome 4 or 8. Alternatively, Tabby could be a unique locus in cats.