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Wiley InterScience | ||||||||||
  CytopathologyVolume 17 Issue 6, Pages 353 - 360 Published Online: 27 Nov 2006 Journal compilation © 2010 Blackwell Publishing Ltd The Official Journal of the British Society for Clinical Cytology and over 20 National affiliated Societies
Abstract | References | Full Text: HTML, PDF (Size: 552K) | Related Articles | Citation Tracking  Interlaboratory reproducibility of atypical glandular cells of undetermined significance: a national survey
Copyright 2006 The Authors Journal compilation 2006 Blackwell Publishing Ltd KEYWORDS AGC • cytology • screening • reproducibility • glandular lesions • cervical adenocarcinoma • cytodiagnosis • diagnosis • cytological techniques • laboratory diagnosis • cervical screening M. Confortini, L. Di Bonito, F. Carozzi, B. Ghiringhello, G. Montanari, F. Parisio, S. Prandi and the GISCi Working Group for Cervical Cytology Interlaboratory reproducibility of atypical glandular cells of undetermined significance: a national survey ABSTRACTObjective: The aim of this study was to evaluate the inter-laboratory reproducibility for atypical glandular cells (AGC) (The Bethesda System (TBS) 2001) of the laboratories involved in the screening programmes in Italy. Methods: A set of 35 selected slides were circulated among 167 laboratories involved in local population-based cervical screening programmes. Each laboratory provided one single diagnosis per smear. The smears were read blind to the original diagnosis and to the diagnoses provided by other laboratories. A 'majority' diagnosis was defined for each case and assumed as the reference standard. The diagnosis provided from each laboratory was compared with the majority diagnosis. Results: According to the majority report the 35 slides in the set were classified as negative in nine cases, AGC in eight, adenocarcinoma in eight, and squamous lesion or squamous + glandular lesion in 10. The crude agreement between all pairs of laboratories was 49.43%. K-values were 0.46, 0.21, 0.34, 0.36 and 0.32 for negative, AGC/AIS (adenocarcinoma in situ of endocervix), AdenoCa, Sq/Sq + Gl and all reporting categories respectively. Concordance according to overall K was moderate to substantial in 77% of the participating laboratories. Conclusions: The present study shows that the AGC category is not easily reproducible. The data confirmed the importance, in a screening scenario, of AGC/AIS diagnoses, but also presented difficulties in differentiating between the two diagnoses. In addition to the results obtained from the circulation of the slides, laboratories which had annually a low number of cervical smears were able to gain experience focused on particular morphological pictures. Accepted for publication 18 April 2006 | 
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Professor Harald zur Hausen is a 2008 Nobel Laureate in Medicine or Physiology. He was recognized "for his discovery of human papilloma viruses causing cervical cancer". Zur Hausen serves as Editor-in-Chief of the 
