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Wiley InterScience | ||||||||||
  Chemical Biology & Drug DesignVolume 67 Issue 4, Pages 297 - 304 Published Online: 18 Apr 2006 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 274K) | Supporting Information | Related Articles | Citation Tracking  Research Article DNA-binding by Functionalized Gold Nanoparticles: Mechanism and Structural Requirements Copyright 2006 The Authors Journal compilation 2006 Blackwell Munksgaard KEYWORDS DNA • intercalator • hydrophobicity • LC ABSTRACTA family of nanoparticles featuring surfaces of varying hydrophobicity was synthesized. The efficiency of DNA-binding was determined, demonstrating in a fivefold modulation in binding a 37-mer DNA strand. Nanoparticle-binding causes a reversible conformational change in the DNA structure, as demonstrated by circular dichroism and fluorescence experiments. Furthermore, the affinity of the nanoparticle for the DNA can be regulated by external agents, though stability of the complex is observed at relatively high ionic strengths. Received 25 February 2006, revised and accepted for publication 14 March 2006 | 
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