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Wiley InterScience | |||||||||||||
  Clinical and Experimental DermatologyVolume 31 Issue 3, Pages 430 - 434 Published Online: 16 Mar 2006 Journal compilation © 2010 British Association of Dermatologists An Official Journal of the British Association of Dermatologists
Abstract | References | Full Text: HTML, PDF (Size: 130K) | Related Articles | Citation Tracking  Experimental dermatology • Original article Does the plasma level of vitamins A and E affect acne condition? Copyright 2006 Blackwell Publishing Ltd Summary
Background. Vitamin A and E are lipid soluble antioxidants that are necessary for our health. Deficiency in these vitamins can cause serious diseases. Administration of vitamin A and E to patients with acne was shown to improve their acne condition. Aims. To test the relationship between plasma vitamin A and E levels and acne. Methods. Plasma vitamin A and E concentrations were determined by high performance liquid chromatography in 100 newly diagnosed untreated patients with acne and were compared with those of 100 age-matched healthy controls. Patients were carefully graded using the Global Acne Grading System. Results. We found that plasma vitamin A concentrations in patients with acne were significantly lower than those of the control group (336.5 vs. 418.1 μg/L, respectively) P = 0.007. We also found that plasma vitamin E concentrations in patients with acne were significantly lower than those of controls (5.4 vs. 5.9 mg/L) P = 0.05. In addition, we found that there is a strong relationship between decrease in plasma vitamin A levels and increase in the severity of acne condition. Patients with severe acne had significantly lower plasma concentrations of vitamins A and E than did those with lower acne grade and the age-matched healthy controls. Discussion. Based on our results, we conclude that low vitamin A and E plasma levels have an important role in the pathogenesis of acne and in the aggravation of this condition. Accepted for publication 21 December 2005 | 
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