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Wiley InterScience | ||||||||||||||||
  Journal of Clinical PeriodontologyVolume 33 Issue 2, Pages 86 - 91 Published Online: 27 Jan 2006 © 2010 John Wiley & Sons A/S The official publication of the European Federation of Periodontology
Abstract | References | Full Text: HTML, PDF (Size: 116K) | Related Articles | Citation Tracking  Anti-gingivitis effect of a dentifrice containing bioactive glass (NovaMin Copyright Copyright © Blackwell Munksgaard 2006 KEYWORDS anti-gingivitis • anti-plaque • bioactive glass
Tai BJ, Bian Z, Jiang H, Greenspan DC, Zhong J, Clark AE, Du MQ. Anti-gingivitis effect of a dentifrice containing bioactive glass (NovaMin Abstract
Background: The objective of this pilot clinical trial was to evaluate the anti-gingivitis and anti-plaque effects of a dentifrice containing bioactive glass (NovaMin Methods: The study design was a randomized, double-blinded, controlled clinical trial. One hundred volunteers took part in the study and were matched for plaque index (PLI), gingival bleeding index (GBI), age and gender. The protocol was reviewed and approved by the Ethical Committee of the University. The subjects received a supragingival prophylaxis to remove all plaque, calculus and extrinsic stain. Following the baseline examination, subjects were instructed to brush with their assigned dentifrice and toothbrush. The PLI and GBI were determined for the baseline and 6 weeks. The data were analysed using a repeated-measures anova conducted on the two dependent measures to compare the effect between the test and control group. Results: Ninety-five subjects finished the study. The results showed that the PLI (baseline=1.54, 6 weeks=1.29) and GBI (baseline=1.14, 6 weeks=0.47) were significantly reduced, respectively, over the 6 weeks period in the test group (p<0.001 for each measure). There was a 58.8% reduction in gingival bleeding and a 16.4% reduction in plaque growth. There was no difference of the PLI (baseline=1.60, 6 weeks=1.57) and GBI (baseline=1.18, 6-week=1.02) over the 6 week period in the control group. Conclusion: This study demonstrated that a dentifrice containing NovaMin Accepted for publication 24 October 2005 | 
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