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Wiley InterScience | |||||||||||||||
  Journal of the European Academy of Dermatology and VenereologyVolume 20 Issue 4, Pages 435 - 439 Published Online: 9 Feb 2006 Journal compilation © 2010 European Academy of Dermatology and Venereology Published on behalf of the European Academy of Dermatology and Venereology
Abstract | References | Full Text: HTML, PDF (Size: 119K) | Related Articles | Citation Tracking  CASE REPORT Minocycline-induced cutaneous hyperpigmentation: confocal laser scanning microscope analysis The authors have no commercial interest, neither current nor over the past 5 years, in any of the drugs mentioned in the manuscript. Copyright © 2006 European Academy of Dermatology and Venereology KEYWORDS confocal microscope • fluorescence • hyperpigmentation • minocycline Abstract
Background Minocycline has a characteristic yellow-green fluorescent emission. This fluorescence has been previously demonstrated only in type 1 minocycline-induced skin hyperpigmentation. Objective To investigate whether the fluorescence can be detected in other types of minocycline-induced cutaneous hyperpigmentation, and to study the possible mechanisms. Methods Biopsies of pigmented and nonpigmented skin from 3 patients with different types of skin hyperpigmentation induced by minocycline were analysed by light microscopy and Confocal Laser Scanning Microscope (CLSM). Results A yellow-green fluorescence was observed in the hyperpigmented skin of two patients with type 2, and one patient with type 4 minocycline–induced cutaneous hyperpigmentation. No fluorescence was detected in the non-pigmented skin. Conclusion Minocycline can possibly serve as a fluorescent probe in the diagnosis of all types of minocycline-induced cutaneous hyperpigmentation. Received: 3 September 2004, accepted: 9 December 2004 DOI: 10.1111/j.1468-3083.2006.01436.x | 
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