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Wiley InterScience | |||||||||||||||||||
  Acta Psychiatrica ScandinavicaVolume 114 Issue 2, Pages 132 - 139 Published Online: 5 Dec 2005 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 118K) | Related Articles | Citation Tracking  Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults Copyright 2006 The Authors Journal Compilation 2006 Blackwell Munksgaard KEYWORDS depression • thyroxine • thyroid-stimulating hormone • hypothyroidism • endophenotypes Forman-Hoffman V, Philibert RA. Lower TSH and higher T4 levels are associated with current depressive syndrome in young adults. ABSTRACTObjective: The relationship of individual thyroid function indices to depression in those without a history of prior thyroid dysfunction is uncertain. Method: We examined the relationship between thyroid-stimulating hormone (TSH) and thyroxine (T4) levels and current or lifetime history of depressive symptoms using information from 6869 participants, aged 17–39 years, in the Third National Health and Nutrition Examination Survey without history of thyroid-related illness. Results: We found that lower TSH and higher T4 levels were associated with current depressive syndrome in men, but only higher T4 levels correlated with current depressive syndrome in women. Lifetime depressive syndrome was associated with neither TSH level nor T4 levels in men or women. Conclusion: These findings suggest that transient or 'state dependent' changes are associated with depression in those without a history of thyroid illness. Further studies to discern whether these depression-associated changes represent distinct endophenotypes of depression should be encouraged. Accepted for publication October 24, 2005 | 
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 | Personality and Mental Health |
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