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Wiley InterScience | ||||||
  XenotransplantationVolume 13 Issue 4, Pages 284 - 288 Published Online: 9 Jun 2006 © 2009 John Wiley & Sons A/S The International Xenotransplantation Association, a section of The Transplantation Society
Abstract | References | Full Text: HTML, PDF (Size: 161K) | Related Articles | Citation Tracking  Review Article Choroid plexus transplants in the treatment of brain diseases Copyright 2006 Blackwell Munksgaard KEYWORDS amyotrophic lateral sclerosis • choroid plexus • encapsulation • Huntington's disease • neurotrophin • spinal cord trauma • stroke Skinner SJM, Geaney MS, Rush R, Rogers M-L, Emerich DF, Thanos CG, Vasconcellos AV, Tan PLJ, Elliott RB. Choroid plexus transplants in the treatment of brain diseases. Xenotransplantation 2006; 13: 284–288. © Blackwell Munksgaard, 2006 ABSTRACTAbstract: The choroid plexus (CP) produces and secretes numerous biologically active neurotrophic factors into the cerebrospinal fluid (CSF). These circulate throughout the brain and spinal cord, maintaining neuronal networks and associated cells. In neurodegenerative disease and in acute brain injury there is local up-regulation of neurotrophin production close to the site of the lesion. Treatment by direct injection of neurotrophins and growth factors close to these lesion sites has repeatedly been demonstrated to improve recovery. It has therefore been proposed that transplanting viable choroid plexus cells close to the lesion might provide a novel means for continuous delivery of these molecules directly to the site of injury. Recent publications describe how transplanted CP, either free or in an immunoprotected encapsulated form, deliver therapeutic molecules to the desired site. This review briefly describes the accumulated evidence that CP cells support neuronal cells in vitro and have therapeutic properties when transplanted to treat acute and chronic brain disease and injury in animal models. Received 20 January 2006; Accepted 25 January 2006 | 
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