Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala

doi:10.1111/j.1460-9568.2006.04962.x

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Wiley InterScience

European Journal of Neuroscience

Volume 24 Issue 3, Pages 876 - 884

Published Online: 14 Aug 2006

Published on behalf of the Federation of European Neuroscience Societies

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Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala

Jason J. Radley ¹ , Luke R. Johnson ^3,4 , William G. M. Janssen ² , Jeremiah Martino ^3,4 , Raphael Lamprecht ^3,4 , Patrick R. Hof ^2,4 , Joseph E. LeDoux ^3,4 and John H. Morrison ^2,4

¹ Laboratory for Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
² Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
³ Center for Neural Science, New York University, New York, NY, USA
⁴ NIMH Conte Center for the Neuroscience of Fear and Anxiety, New York, NY, USA

Correspondence to Jason J. Radley, as above.
E-mail: radley@salk.edu

Copyright The Authors (2006). Journal Compilation Federation of European Neuroscience Societies and Blackwell Publishing Ltd

KEYWORDS

dendritic spine • electron microscopy • fear conditioning • immunohistochemistry • learning • rat • spinophilin

ABSTRACT

Changes in dendritic spine number and shape are believed to reflect structural plasticity consequent to learning. Previous studies have strongly suggested that the dorsal subnucleus of the lateral amygdala is an important site of physiological plasticity in Pavlovian fear conditioning. In the present study, we examined the effect of auditory fear conditioning on dendritic spine numbers in the dorsal subnucleus of the lateral amygdala using an immunolabelling procedure to visualize the spine-associated protein spinophilin. Associatively conditioned rats that received paired tone and shock presentations had 35% more total spinophilin-immunoreactive spines than animals that had unpaired stimulation, consistent with the idea that changes in the number of dendritic spines occur during learning and account in part for memory.

Received 3 May 2006, revised 4 May 2006, accepted 30 May 2006

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1460-9568.2006.04962.x About DOI

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