|
If you are seeing this message, you may be experiencing temporary network problems. Please wait a few minutes and refresh the page. If the problem persists, you may wish to report it to your local Network Manager.
It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to help minimise these problems.
Wiley InterScience | |||||||||
  Pediatric DiabetesVolume 7 Issue 5, Pages 260 - 266 Published Online: 18 Oct 2006 © 2010 John Wiley & Sons A/S
Abstract | References | Full Text: HTML, PDF (Size: 124K) | Related Articles | Citation Tracking  Original Article Use of markers of dyslipidemia to identify overweight youth with insulin resistance Copyright 2006 The Authors Journal compilation KEYWORDS insulin sensitivity • high-density lipoprotein cholesterol • hyperinsulinemic–euglycemic clamp • obesity • triglycerides Hannon TS, Bacha F, Lee SJ, Janosky J, Arslanian SA. Use of markers of dyslipidemia to identify overweight youth with insulin resistance. ABSTRACTContext: Markers to identify overweight youth with insulin resistance are of clinical importance. Objective: To determine if markers of dyslipidemia could identify overweight adolescents with insulin resistance. Setting, Participants, and Study Design: We retrospectively examined the association between markers of dyslipidemia and insulin resistance in 35 overweight [body mass index (BMI) of ≥95th percentile], white adolescents [mean age 13.5 ± (SD) 1.6 yr] who had participated in hyperinsulinemic–euglycemic clamp studies to evaluate insulin action. Total body fat was measured by dual-energy X-ray absorptiometry and abdominal fat with computed tomography. Using receiver-operating curves, cut-points for triglyceride (TG)/high-density lipoprotein (HDL) and TG level to identify overweight individuals in the lowest tertile for insulin sensitivity were determined. Main Outcome Measure: Difference in the values for insulin sensitivity among the groups. Results: Of the markers examined (TG, TG/HDL, adiponectin, measures of adiposity and fasting insulin), fasting insulin was the strongest correlate of insulin sensitivity (r = 0.87, p < 0.001). Youth with TG/HDL level ≥3 had lower insulin sensitivity (50% lower median values, p < 0.01) and higher visceral fat (p < 0.05) despite BMI comparable to that of youth with TG/HDL level <3. Youth with TG/HDL ≥3 had a sensitivity of 61% and specificity of 82% for identifying participants with the greatest degree of insulin resistance. Conclusions: TG and TG/HDL are easily obtained markers associated with insulin resistance. Further research is needed to determine if a constellation of clinical findings, such as components of the metabolic syndrome along with other metabolic markers including adiponectin, better predicts insulin resistance in overweight youth. Submitted 11 January 2006. Accepted for publication 27 April 2006 | 
|
