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Wiley InterScience

International Journal of Dermatology

International Journal of Dermatology

Volume 44 Issue 12, Pages 981 - 988

Published Online: 6 Oct 2004

Journal compilation © 2010 International Society of Dermatology



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Pharmacology and therapeutics
Ivermectin: pharmacology and application in dermatology
Assen L. Dourmishev , Lyubomir A. Dourmishev , and Robert A. Schwartz
  From the Department of Dermatology and Venereology, Medical University, Sofia, Bulgaria, and the Department of Dermatology, New Jersey Medical School, Newark, NJ
Correspondence to  Prof. Assen L. Dourmishev, phd, dsc Department of Dermatology and Venereology Medical University 1 St. G. Sofiisky Street 1431 Sofia Bulgaria E-mail: Assen_Dourmishev@yahoo.com
Copyright © 2004 The International Society of Dermatology

Abstract

AbstractIntroductionPharmacokinetcsPharmacology, Toxicology, Carcinogenesis and TeratogenicityMode of ActionReferences

Ivermectin is a synthetic derivative of the antiparasitic class of compounds known as avermectins. It is a macrolide endectocide with activity against both endoparasites with cutaneous tropism (Strongyloides stercoralis, Ancylostoma braziliense, Cochliomyia hominivorax, Dermatobia hominis, Filaria bancrofti, Wucheria malayi, Onchocerca volvulus, Loa-loa) and ectoparasites such as Sarcoptes scabies, Pediculus humanus, Demodex folliculorum, and Cheyletiella sp. Ivermectin is of great interest in the treatment of patients with different forms of scabies, head lice, demodecidosis, cutaneous larva migrans, cutaneous larva currens, myiasis, and filariasis.


DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1365-4632.2004.02253.x About DOI

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