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Wiley InterScience | |||||||
  Psychiatry and Clinical NeurosciencesVolume 59 Issue 5, Pages 613 - 615 Published Online: 30 Sep 2005 Journal compilation © 2010 Japanese Society of Psychiatry and Neurology Official Journal of the Japanese Society of Psychiatry and Neurology
Abstract | References | Full Text: HTML, PDF (Size: 39K) | Related Articles | Citation Tracking  Short Communication Management of atypical antipsychotic-induced weight gain in schizophrenic patients with topiramate Copyright 2005 Blackwell Science Pty Ltd KEYWORDS atypical antipsychotics • obesity • schizophrenia • topiramate ABSTRACTAbstract Patients treated with atypical antipsychotic drugs commonly gain excess weight. Because obesity is associated with considerable morbidity and decreased life expectancy, treatment of weight gain in these patients is critical. Topiramate, a fairly new anticonvulsant, promotes bodyweight loss in healthy obese subjects, patients with bipolar disorder, and patients with eating disorder. However, there are very few reports about the efficacy of topiramate for weight management in schizophrenic patients. We present the cases of three Taiwanese patients with schizophrenia whose bodyweight increased as a result of atypical antipsychotics treatment, then was controlled by topiramate without aggravation of their psychotic symptoms. Received 15 November 2004; revised 22 February 2005; accepted 3 April 2005. | 
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