Group IIA phospholipase A2 concentration of tears in patients with ocular rosacea

doi:10.1111/j.1600-0420.2005.00495.x

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Wiley InterScience

Acta Ophthalmologica Scandinavica

Volume 83 Issue 4, Pages 483 - 486

Published Online: 19 Jul 2005

2007 The Authors Journal Compilation 2007 Acta Ophthalmol Scand.

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Group IIA phospholipase A₂ concentration of tears in patients with ocular rosacea

Osmo Kari ¹ , Valtteri V. Aho ² , Sirje Peltonen ¹ , Jukka M. Saari ³ , Marjatta Kari ⁴ , Marko Määttä ³ , Yrjö Collan ⁵ and K. Matti Saari ² *

¹ Department of Allergology, University of Helsinki, Helsinki, Finland
² Department of Ophthalmology, University of Turku, Turku, Finland
³ Department of Ophthalmology, University of Helsinki, Helsinki, Finland
⁴ Department of Statistics, University of Turku, Turku, Finland
⁵ Department of Pathology, University of Turku, Turku, Finland

Correspondence to *K. Matti Saari MD
Professor of Ophthalmology
Department of Ophthalmology
University of Turku
FIN-20520 Turku
Finland
Tel: + 358 2 313 0000
Fax: + 358 2 313 2595
Email: kmsaari@kolumbus.fi

KEYWORDS

blepharitis • conjunctivitis • dry eye • eosinophils • keratitis • meibomian glands • phospholipase A₂ • rosacea • tears

Abstract.

Purpose: To determine the concentration of group IIA phospholipase A₂ (GIIAPLA₂) in tears of patients with ocular rosacea, and to compare it with GIIAPLA₂ concentration in tears of age-matched healthy controls.

Methods: The GIIAPLA₂ concentration in tears was measured with a time-resolved fluoroimmunoassay in 21 patients with ocular rosacea (mean age 55.6±9.2 years) and in 21 normal subjects (mean age 53.4±8.2 years). Conjunctival brush cytology was carried out and eosinophils, neutrophils, lymphocytes, squamous epithelial cells, columnar epithelial cells, metaplastic changes and goblet cells were calculated separately.

Results: The GIIAPLA₂ concentration in tears was statistically significantly lower in patients with ocular rosacea (31.0±18.4 µg/ml, p=0.0099) and, more specifically, in patients who had dry eye (25.8±15.1 µg/ml, p=0.0034), compared to that in normal controls. There was no correlation between the GIIAPLA₂ content of tears and the conjunctival cells collected by the brush cytology.

Conclusion: The tears of patients with dry eye symptoms due to ocular rosacea have decreased GIIAPLA₂ content. The pathogenic importance of this finding is discussed.

Received on April 28th, 2004.
Accepted on April 2nd, 2005.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1600-0420.2005.00495.x About DOI