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Wiley InterScience

FEBS Journal

FEBS Journal

Volume 272 Issue 9, Pages 2088 - 2097

Published Online: 21 Apr 2005

Journal compilation © 2010 Federation of European Biochemical Societies



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MINIREVIEW
Protein families and RNA recognition
Yu Chen 1 and Gabriele Varani 1,2
  Department of Chemistry, University of Washington, Seattle, WA, USA
  Department of Biochemistry, University of Washington, Seattle, WA, USA
Correspondence to G. Varani, Department of Chemistry University of Washington, Seattle, WA 98195–1700, USA
Fax: +1 206 6858665
E-mail: varani@chem.washington.edu
Copyright 2005 FEBS

ABSTRACT

This minireview series examines the structural principles underlying the biological function of RNA-binding proteins. The structural work of the last decade has elucidated the structures of essentially all the major RNA-binding protein families; it has also demonstrated how RNA recognition takes place. The ribosome structures have further integrated this knowledge into principles for the assembly of complex ribonucleoproteins. Structural and biochemical work has revealed unexpectedly that several RNA-binding proteins bind to other proteins in addition to RNA or instead of RNA. This tremendous increase in the structural knowledge has expanded not only our understanding of the RNA recognition principle, but has also provided new insight into the biological function of these proteins and has helped to design better experiments to understand their biological roles.


(Received 16 December 2004, accepted 7 March 2005)

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1742-4658.2005.04650.x About DOI

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