β2-Adrenergic Receptor Gene Variations Associated with Stage-2 Hypertension in Northern Han Chinese

doi:10.1046/j.1529-8817.2003.00093.x

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Wiley InterScience

Annals of Human Genetics

Volume 69 Issue 1, Pages 36 - 44

Published Online: 8 Dec 2004

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β2-Adrenergic Receptor Gene Variations Associated with Stage-2 Hypertension in Northern Han Chinese

D. Ge ^1,2 , J. Huang ¹ , J. He ³ , B. Li ⁴ , X. Duan ¹ , R. Chen ⁴ and D. Gu ^1,2,*

¹ Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China ² National Human Genome Center at Beijing, North Yongchang Rd 3-707, 100176 ³ Tulane University Medical Center, New Orleans, LA 70112-2699, USA ⁴ Institute of Biophysics Academia Sinica, Datun Rd. 15, Beijing, 100101, China

*Author for correspondence: Dongfeng Gu, MD, MS. Division of Population Genetics and Prevention, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China, Tel +86 (10) 6833 1752. Fax +86 (10) 8836 3812. E-mail: gudf@yahoo.com

KEYWORDS

hypertension • blood pressure • association study

Summary

The aim of this study was to investigate the association between polymorphisms in the β₂-adrenergic receptor gene (ADRB2) (−47C/T, Arg16/Gly, Gln27/Glu) and stage-2 hypertension in northern Han Chinese. We recruited 503 individuals with stage-2 hypertension and 504 age-, gender-, and area-matched controls from the International Collaborative Study of Cardiovascular Disease in Asia. Genotyping was performed using PCR-RFLP. Logistic regression analyses revealed that carriers of the Gly16 allele had a significantly higher odds ratio (OR) for hypertension, while carriers of the Glu27 allele had a significantly lower OR. In multivariate linear regression analyses, the Arg16/Gly and Gln27/Glu genotypes were significantly associated with systolic blood pressure level (p= 0.004 and p < 0.001, respectively). In haplotype analyses, we found the frequency of haplotypes composed of the Gly16 and Gln27 alleles was significantly higher, whereas the frequency of haplotypes composed of the Arg16 and Glu27 alleles was significantly lower, in hypertensives compared to their controls (both p= 0.001). These results indicate that the Gly16 and Gln27 alleles of the ADRB2 gene confer an increased risk for stage-2 hypertension in this northern Han Chinese population.

Received: 11 August 2003
Accepted: 3 November 2003

DIGITAL OBJECT IDENTIFIER (DOI)

10.1046/j.1529-8817.2003.00093.x About DOI