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Prophylactic Use of Sustained-Release Doxycycline Blocks Tick-Transmitted Infection by Anaplasma phagocytophilum in a Murine Model
ROBERT F. MASSUNG a , NORDIN S. ZEIDNER b , MARC C. DOLAN b , DAWN ROELLIG a , ELIZABETH GABITZSCH b , DANIELLE R. TROUGHTON a , MICHAEL L. LEVIN a
  a Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA   b Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Ft. Collins, Colorado, USA
 Address for correspondence: Robert F. Massung, Centers for Disease Control and Prevention, 1600 Clifton Rd., MS G-13, Atlanta, GA 30333. Voice: 404-639-1082; fax: 404-639-4436. rfm2@cdc.gov
Copyright 2005 Annals of the New York Academy of Sciences
KEYWORDS
Anaplasma phagocytophilum • Ixodes scapularis • doxycycline • human granulocytic anaplasmosis • treatment

Abstract:

AbstractREFERENCES

Abstract: A sustained-release formulation of doxycycline hyclate was tested for its ability to block Anaplasma phagocytophilum infection in mice. Mice treated with sustained-release doxycycline showed no splenomegaly and their blood samples were negative by PCR on days 7, 14, and 21. Control mice treated with either oral doxycycline or water had significant splenomegaly and were PCR positive at multiple time points. The sustained-release doxycycline formulation was shown to be efficacious for preventing tick-transmitted A. phagocytophilum infection in a mouse model.

DIGITAL OBJECT IDENTIFIER (DOI)
10.1196/annals.1355.080 About DOI

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