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Wiley InterScience | ||||||||||||
  Journal of Cosmetic DermatologyVolume 4 Issue 4, Pages 258 - 261 Published Online: 5 Dec 2005 © 2009 Wiley Periodicals, Inc. The official journal of the International Academy of Cosmetic Dermatology
Abstract | References | Full Text: HTML, PDF (Size: 94K) | Related Articles | Citation Tracking  Original Contributions A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia Copyright © 2005 Blackwell Publishing KEYWORDS female pattern alopecia • niacin • niacin derivatives • topical delivery Summary
Background Female pattern alopecia is a common dermatologic condition that manifests after puberty. The only approved drug treatment for this condition is 2% minoxidil for topical application. Aims This pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate and tetradecyl nicotinate, on hair fullness in female alopecia. Patients/methods Sixty female subjects with Ludwig types I–III female pattern hair loss were evaluated in a double-blinded, placebo-controlled (40 active, 20 placebo) design using standardized 35-mm photographic analyses for assessment of efficacy after 6 months of application. Results The niacin derivatives demonstrated a statistically significant increase in hair fullness (P = 0.04 compared to the placebo). Conclusion Whereas evaluation of hair growth in women is challenging, this 6-month pilot study demonstrated statistically significant increase in hair fullness on blinded 35-mm photographic analysis. Long-term topical application of nicotinic acid derivatives offers promise for providing benefit in female alopecia and warrants further study. Accepted for publication August 4, 2005 | 
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