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Wiley InterScience | ||
![]() Immunology and Cell BiologyVolume 82 Issue 3, Pages 307 - 314 Published Online: 28 Jun 2008 2006 The Authors Journal compilation
Abstract | References | Full Text: HTML, PDF (Size: 941K) | Related Articles | Citation Tracking Special Feature CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity Copyright 2004 Australian Society for Immunology Inc. KEYWORDS autoimmunity • dendritic cell • diabetes • immunoregulation • iNKT cell ABSTRACTSummary CD1-restricted T cells have been shown to play a critical role in host defence, tumour surveillance, and maintenance of tolerance. However, immunologic outcomes resulting from activation of CD1d-restricted T cells can be either beneficial or deleterious. A major mechanism by which CD1d-restricted T cells are thought to exert immunoregulatory control is via effects on dendritic cell (DC) differentiation and migration. Important functional subsets of CD1d-restricted T cells are also known to exist and the potential implications for preferential subset activations are discussed. Received 11 March 2004; accepted 11 March 2004. |