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Wiley InterScience

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Special Feature
CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity
Paul L Bollyky and S Brian Wilson
  Diabetes Research Laboratories, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
 Correspondence: S. Brian Wilson, MD, PhD, Diabetes Research Laboratories, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA. Email: bwilson@rics.bwh.harvard.edu
Copyright 2004 Australian Society for Immunology Inc.
KEYWORDS
autoimmunity • dendritic cell • diabetes • immunoregulation • iNKT cell

ABSTRACT

Summary CD1-restricted T cells have been shown to play a critical role in host defence, tumour surveillance, and maintenance of tolerance. However, immunologic outcomes resulting from activation of CD1d-restricted T cells can be either beneficial or deleterious. A major mechanism by which CD1d-restricted T cells are thought to exert immunoregulatory control is via effects on dendritic cell (DC) differentiation and migration. Important functional subsets of CD1d-restricted T cells are also known to exist and the potential implications for preferential subset activations are discussed.


Received 11 March 2004; accepted 11 March 2004.

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.0818-9641.2004.01253.x About DOI

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