A MULTICENTER RANDOMIZED CONTROLLED TRIAL DESIGNED TO EVALUATE FOLLOW-UP SURVEILLANCE STRATEGIES FOR COLORECTAL CANCER: THE JAPAN POLYP STUDY

doi:10.1111/j.1443-1661.2004.00417.x

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Wiley InterScience

Digestive Endoscopy

Volume 16 Issue 4, Pages 376 - 378

Published Online: 8 Sep 2004

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CLINICAL TRIAL NOTE

A MULTICENTER RANDOMIZED CONTROLLED TRIAL DESIGNED TO EVALUATE FOLLOW-UP SURVEILLANCE STRATEGIES FOR COLORECTAL CANCER: THE JAPAN POLYP STUDY

Yasushi Sano*, Takahiro Fujii ^† , Yasushi Oda ^‡ , Takahisa Matsuda ^§ , Takahiro Kozu ^§ , Shin-ei Kudo ^¶ , Masahiro Igarashi**, Hiroyasu Iishi ^†† , Kuang-I Fu ^‡‡ , Kazuhiro Kaneko ^§§ , Kinichi Hotta ^¶¶ , Takayuki Yoshino***, Hideki Ishikawa ^††† , Yoshitaka Murakami ^‡‡‡ , Tadakazu Shimoda ^§§§ , Takahiro Fujimori ^‡‡ , Yoichi Ajioka ^¶¶¶ , Toru Otani****, Hiroshi Saito ^†††† , Atsushi Ochiai ^‡‡‡‡ , Shigeaki Yoshida* and the Japan Polyp Study Workgroup*****

*Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba,
^† TF Clinic, Tokyo,
^‡ Hattori GI Endoscopy and Gastroenterology Clinic, Kumamoto,
^§ Division of Endoscopy, National Cancer Center Hospital, Tokyo,
^¶ Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama,
**Department of Gastroenterology, Kitasato University East Hospital, Sagamihara,
^†† Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka,
^‡‡ Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi,
^§§ Second Department of Internal Medicine, Showa University School of Medicine, Tokyo,
^¶¶ Department of Internal Medicine, Saku Central Hospital, Nagano,
***Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka,
^††† Laboratory Hereditary Tumor, Institute for Advanced Medical Science, Hyogo College of Medicine, Osaka,
^‡‡‡ Epidemiology and International Health Research Section, Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki,
^§§§ Pathology Clinical Laboratory Division, National Cancer Center Hospital, Tokyo,
^¶¶¶ First Department of Pathology, Niigata University School of Medicine, Niigata,
****Medical Research Support, Osaka,
^†††† Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo and
^‡‡‡‡ Pathology Division, National Cancer Center Research Institute East, Chiba, Japan

Correspondence to Yasushi Sano, National Cancer Center Hospital East, Division of Digestive Endoscopy and Gastrointestinal Oncology, Kashiwanoha 6-5-1, Kashiwa, Chiba 277-8577, Japan. Email: ysano@east.ncc.go.jp

KEYWORDS

colorectal tumors • randomized controlled trial (RCT) • study overview • the Japan Polyp Study (JPS)

ABSTRACT

Colorectal cancer is the third leading cause of cancer mortality, and the incidence of colorectal cancer in Japan is increasing gradually. To reduce colorectal cancer mortality, a higher compliance for colorectal cancer screening and follow-up programs is needed. Consequently, it is necessary to establish firm recommendations based on strong evidence from postpolypectomy colonoscopic surveillance. The Japan Polyp Study (JPS) began in 2000, and its objective is to evaluate follow-up surveillance strategies in patients who have undergone two complete colonoscopies for the control of colorectal cancer, with the removal of all detected polyps by high-resolution chromoendoscopy, including the removal of flat or superficial depressed (0-IIc) lesions. The JPS is scheduled to continue until the year 2010, and future data will help to develop recommendations for surveillance guidelines for such patients.

Received 8 March 2004; accepted 5 April 2004.

DIGITAL OBJECT IDENTIFIER (DOI)

10.1111/j.1443-1661.2004.00417.x About DOI