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Wiley InterScience | |||||||||||||||||
  Veterinary SurgeryVolume 32 Issue 6, Pages 539 - 544 Published Online: 24 Jan 2005 © 2010 American College of Veterinary Surgeons
Abstract | References | Full Text: HTML, PDF (Size: 160K) | Related Articles | Citation Tracking  Pasteurized tumoral autograft and adjuvant chemotherapy for the treatment of canine distal radial osteosarcoma: 13 cases Presented in part at the 11th European College of Veterinary Surgeons meeting, July 5-7, 2002, Vienna, Austria. Copyright 2003 by The American College of Veterinary Surgeons ©Copyright 2003 by The American College of Veterinary Surgeons ABSTRACTObjective—To report outcome in 13 dogs with distal radial osteosarcoma, without evidence of metastasis, treated by a combination of adjuvant chemotherapy and a pasteurized autograft limb-sparing procedure. Study Design—Prospective clinical study. Animals—Thirteen dogs with distal radial osteosarcoma. Methods—Limb-sparing procedure was performed using an autograft from the excised tumoral segment, pasteurized at 65°C for 40 minutes. Adjuvant chemotherapy (cisplatin or cisplatin and doxorubicin) was administered in all dogs. Results—Mean and median survival times were 531 and 324 days, respectively (range, 180 to 1,868 days). Overall survival was 100% at 6 months, 50% at 12 months, 44% at 18 months, and 22% at 24 months. Lung metastasis occurred in 5 (38%) dogs. Observed complications were local recurrence (2 dogs, 15%), allograft infection (4 dogs, 31%), and implant failure (3 dogs, 23%). Limb function was good in 12 dogs (92%) and fair in 1 dog. Conclusions—Pasteurized bone autograft derived from the tumoral bone segment was an effective alternative to cortical bone allograft for limb sparing in canine distal radial osteosarcoma, in terms of feasibility, pattern of healing, complications, and survival. Clinical Relevance—Use of a pasteurized bone autograft eliminates the need for a canine bone allograft bank and has the added advantage of good fit to the recipient site. | 
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