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Wiley InterScience | ||||||||||||||||||||||||
  Annals of Human GeneticsVolume 67 Issue 4, Pages 357 - 366 Published Online: 15 Jul 2003 Journal compilation © 2010 Blackwell Publishing Ltd/University College London
Abstract | References | Full Text: HTML, PDF (Size: 113K) | Related Articles | Citation Tracking  A Marginal Likelihood Model for Family-Based Data Copyright 2003 University College London Summary
This paper presents a marginal likelihood model for family-based data based upon the transmission of marker alleles from each heterozygous parent to his/her affected children. The proposed model, extending the maximum-likelihood-binomial (MLB) method and the disequilibrium maximum-likelihood-binomial (DMLB) method (Abel et al. 1998; Abel & Müller-Myhsok, 1998; Huang & Jiang, 1999), is adaptive to linkage disequilibrium (LD) and linkage heterogeneity. Compared with other procedures, the likelihood ratio test (LRT) derived from the proposed model enjoys superior qualities. First, simulations indicate that the power of the LRT is greater than that of the TDT or DMLB in all of our studied scenarios. Second, when we applied the LRT and other tests to a Tourette Syndrome data, the result was data favorable to the use of the LRT. Therefore, we recommend the use of the LRT as an additional linkage test wherever applicable, especially when the amount of LD is uncertain. Received: 18 February 2002 Accepted: 31 January 2003 | 
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