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Wiley InterScience | |||||||||||
  Australasian Journal of DermatologyVolume 44 Issue 1, Pages 67 - 70 Published Online: 10 Feb 2003 Journal compilation © 2010 The Australasian College of Dermatologists
Abstract | References | Full Text: HTML, PDF (Size: 2949K) | Related Articles | Citation Tracking  CASE REPORT O'Brien's actinic granuloma in association with prolonged doxycycline phototoxicity Davin S Lim, MB BS. Joe Triscott, FRCPA. Copyright 2003 Blackwell Publishing Asia Pty Ltd KEYWORDS drug photosensitivity • elastase • malaria prophylaxis • O'Brien's granuloma • ultraviolet A SUMMARY
O'Brien's actinic granuloma is clinically characterized by annular papules and plaques on sun-exposed areas of skin. These lesions often occur insidiously on a background of severe solar elastosis; however, an acute variant following sunburn has been reported in the literature. We present two cases of acute actinic granuloma precipitated by episodes of sunburn occurring on a background of prolonged doxycycline phototoxicity. Biopsies from both patients showed a histiocytic infiltrate with multinucleate giant cells engulfing elastotic material, with a reduction of elastin towards the centre of the papule. Marked resolution of the lesions was noted after 8 weeks of treatment with betamethasone dipropionate 0.05% ointment in optimized vehicle together with adequate photoprotection in the form of broad-spectrum sunscreens. Submitted 27 February 2002; accepted 15 August 2002. | 
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