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Wiley InterScience | ||
  Risk AnalysisVolume 23 Issue 1, Pages 143 - 162 Published Online: 19 Feb 2003 ©2009 Society for Risk Analysis Published on behalf of the Society for Risk Analysis
Abstract | References | Full Text: HTML, PDF (Size: 209K) | Related Articles | Citation Tracking  Challenges Confronting Risk Analysis of Potential Thyroid Toxicants Copyright 2003 The Society for Risk Analysis KEYWORDS Thyroid hormone • brain development • developmental neurotoxicity • thyroid toxicity • perchlorate • polychlorinated biphenyl ABSTRACTScreening and testing for potential thyroid toxicants using endpoints of thyroid function, including circulating levels of thyroid hormones and thyrotropin, will not capture toxicants that directly interfere with thyroid hormone action at the receptor. The goals of the present review are to provide a critique of the literature focused on thyroid hormone and brain development as it relates to testing and evaluating thyroid toxicants, and to propose possible solutions to this perceived dilemma. |  |
