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Wiley InterScience | |||||||||||||||||||||
  Journal of Applied MicrobiologyVolume 95 Issue 4, Pages 853 - 860 Published Online: 22 Aug 2003 Journal compilation © 2010 The Society for Applied Microbiology The Official Journals of the Society for Applied Microbiology
Abstract | References | Full Text: HTML, PDF (Size: 114K) | Related Articles | Citation Tracking  Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil Copyright 2003 The Society for Applied Microbiology KEYWORDS
Candida albicans
• 1,8-cineole • monoterpenes • tea tree oil • terpinen-4-ol k.a. hammer, c.f. carson and t.v. riley. 2003.
Abstract
Aims:To investigate the in vitro antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. Methods and Results:Activity was investigated by broth microdilution and macrodilution, and time kill methods. Components showing the most activity, with minimum inhibitory concentrations and minimum fungicidal concentrations of ≤0·25%, were terpinen-4-ol, α-terpineol, linalool, α-pinene and β-pinene, followed by 1,8-cineole. The remaining components showed slightly less activity and had values ranging from 0·5 to 2%, with the exception of β-myrcene which showed no detectable activity. Susceptibility data generated for several of the least water-soluble components were two or more dilutions lower by macrodilution, compared with microdilution. Conclusions:All tea tree oil components, except β-myrcene, had antifungal activity. The lack of activity reported for some components by microdilution may be due to these components becoming absorbed into the polystyrene of the microtitre tray. This indicates that plastics are unsuitable as assay vessels for tests with these or similar components. Significance and Impact of the Study:This study has identified that most components of tea tree oil have activity against a range of fungi. However, the measurement of antifungal activity may be significantly influenced by the test method. 2003/159: received 26 February 2003, revised and accepted 13 June 2003 | 
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